Comparative Biosciences

Exploratory proof-of-concept ocular toxicology and tolerability studies, and complete preclinical GLP toxicology and safety assessment studies suitable for regulatory submission for ophthalmic drugs, biologics, antibodies, proteins, and devices.

Immunohistochemistry services provided by Comparative Biosciences for specialized tissues from a range of common and unusual research and discovery models in non-GLP and GLP environments.

Specialized contract histopathology and immunohistochemistry assays for ocular tissue evaluation.

Paraffin, plastic and cryosections for routine, special and immunohistochemical staining, alongside digital image analysis and morphometry.

Expert contract histologic slide preparation and regulatory pathology evaluation of tissues supporting GLP and non-GLP toxicology studies, pharmacology and efficacy studies, basic research, and diagnostics.

Specialized preclinical ocular pharmacology and ophthalmology study services.

In-house histopathology lab offering a wide range of preclinical contract histology and pathology research and development services.

Complete regulatory toxicology program to support GLP IND, veterinary, and BLA-enabling regulatory submissions for small and large molecules, medical devices, and biologics.

Comprehensive safety evaluation and biocompatibility testing services for medical devices, including in vivo assays, safety pharmacology, and in vitro assays.

High-quality preparation of rodent joints from inflammation and arthritis models including decalcification, orientation, sectioning, and scoring.

A complete program of preclinical toxicology services to support a range of your toxicology requirements including single dose, multiple dose, targeted studies, and IND-enabling toxicology programs.

Preclinical contract research services specializing in stem cell toxicology, pharmacokinetics, biodistribution, and efficacy studies for biopharmaceutical and academic organizations.

Preclinical cardiovascular pharmacology services and efficacy models.

Preclinical pharmacology and efficacy models focused on inflammatory pathways and diseases.

Standard immunohistochemistry staining on tissues from all species from fixed and frozen tissues and cytospin preparations.

Fast and cost-effective research programs designed to assess, characterize, and rank new drug therapies for toxicity and efficacy, ranging from non-GLP exploratory toxicity studies to GLP regulatory submission support.

Contract histopathology and immunohistochemistry interpretation services by ACVP board certified veterinary pathologists.

GLP toxicology studies tailored for ophthalmic research candidates.

Comparative Biosciences provides a complete range of device histopathology assessments, including macroscopic dissection, sample preparation, photographic documentation, plastic sectioning and ground sections for implants, metals, plastics, and polymers.

Extensive experience in cardiac, pulmonary and vascular pharmacology modeling, including atherosclerosis, pulmonary hypertension, LAD model and balloon angioplasty with stents.

Preclinical contract research services for ototoxicity and auditory studies, including GLP and non-GLP toxicology, pharmacokinetics, and pharmacology associated with the ear.

Histopathology assessment and ground sectioning for ophthalmic implants.

Customized, investigative, and specialized surgical CNS pharmacology and efficacy models including GLP and NonGLP CNS toxicity studies, pharmacokinetics, and behavioral evaluations.

Preclinical ophthalmic pharmacokinetic, pharmacodynamic and biodistribution study capabilities offered by Comparative Biosciences, evaluating various formulations and administration routes.

Complex investigative toxicology programs designed to address unanticipated or unusual toxicologic or pharmacological events, novel tolerability, efficacy, or specialized pharmacology studies.

Expert scientific resources and quality service providing extensive experience in GLP and non-GLP preclinical toxicology on all laboratory species.

Exploratory and proof-of-concept preclinical ophthalmology studies.

Histochemical stain service using periodic acid–Schiff (PAS).

Routine histochemical stain service using hematoxylin and eosin.

Histochemical stain service using Nile red.

Histochemical stain services including various silver/gold stains and Verhoeff Van Gieson for elastin.

Histochemical stain service using Masson's trichrome method.

Histochemical stain service using toluidine blue.

Histochemical stain service using PAS light green.

In vivo toxicity, irritation, implantation, and biocompatibility studies for medical devices and combination products.

Histochemical stain service using Safranin-O.

Preclinical collagen-induced arthritis model including DBA-1 models for efficacy and pharmacology studies.

Histochemical stain service using the Brown and Brenn method.

Investigative studies evaluating the combined toxicity and efficacy of stem cell therapies and medical devices.

Preparation of gelatin or nongelatin aortas and brachiocephalic arteries in rodent atherosclerosis models with special staining and serial sectioning.

Translational preclinical studies bridging bench research to clinical applications.

Histochemical stain service using Movat's pentachrome method.

Preclinical animal model service for testing test article efficacy on hypertrophic scar formation using a rabbit ear lesion model, including histopathology and quantitative assessments.

Histochemical stain service using Gordon's reticulin method.

Histochemical stain service using Sirius red for polarized light and fibrosis evaluation.

Preclinical adjuvant-induced arthritis model for efficacy and pharmacology studies.

Histochemical stain service using May Grunwald Giemsa.

Comprehensive pharmacology, efficacy, and pharmacokinetics-pharmacodynamics studies conducted across diverse therapeutic areas.

Histochemical stain service using Gomori's modified silver method.

Histochemical stain service using Gomori's trichrome method.

Histopathology assessment and ground sectioning for drug-coated beads.

Histopathology assessment and ground sectioning for implanted suture materials and catheters.

Histochemical stain service for fat detection.

Preclinical contract otic studies including exploratory, proof-of-concept, GLP toxicology, pharmacokinetics, and in vivo animal models for the outer, middle, and inner ear.

Preclinical ovalbumin-induced arthritis model for efficacy and pharmacology studies.

Histochemical stain service for melanin visualization.

Comprehensive immunohistochemical assessment services to evaluate potential cross-reactivity of monoclonal antibodies and biologics with human and animal tissues to support IND and CTA applications.

In-house validated laser-induced choroidal neovascularization model in mini pigs suitable for assessing test article activity in posterior segment proliferative disease.

Histopathology assessment and ground sectioning for mineralized or demineralized tissue samples.

Histochemical stain service for myelin visualization.

Histochemical stain service for TRAP (tartrate-resistant acid phosphatase) targeting osteoclasts.

Customized orthopedic and joint surgical models for testing treatments and devices.

Specialized preparation, staining, and assessment of infarction models such as myocardial infarction and MCOA stroke.

Murine pulmonary fibrosis model induced by continuous SC infusion of bleomycin via osmotic pump for evaluation of pulmonary fibrosis and inflammation.

Histopathology assessment and ground sectioning for stem cell delivery and regenerative medicine devices.

Expert high-quality contract research services providing toxicology, pharmacokinetic, and pharmacology studies in all relevant veterinary species for the veterinary and animal health industry.

Histochemical stain service using Von Kossa method for calcium salts detection.

Oncology pharmacology and xenograft model studies for anti-cancer therapeutic evaluation.

Comprehensive research services related to preclinical pharmacokinetics, toxicokinetics, bioavailability, bioequivalence, and ADME studies.

Histopathology assessment and ground sectioning for artificial cartilage and cartilage implants.

Histopathology assessment and ground sectioning for metallic intravascular stents and vascular filters.

Established in-house validated Laser-induced Choroidal Neovascularization model in mini pigs suitable for assessing test article activity in posterior segment proliferative disease.

Histochemical stain service for copper detection.

Preclinical contract research service for evaluating pulmonary arterial hypertension (PAH) using monocrotaline induction in rat models, including hemodynamic measurements, histopathology, and histomorphometry.

Specialized contract research services for dermatology drugs, biologics, and devices spanning discovery through regulatory submission.

Comprehensive preclinical dermal toxicology program supporting the development of dermatology drugs, biologics, and devices with specialized study services.

Preclinical MSU-induced arthritis model for gout, including intraperitoneal and air pouch inflammation.

Histopathology assessment and ground sectioning for bone cements.

Histochemical stain service for iron detection.

Histopathology assessment and ground sectioning for total hip prosthesis implants.

Tailored and surgical pharmacology and pharmacokinetic study designs to meet unique investigative requirements.

Preclinical research services evaluating dermal pharmacokinetics, bioavailability, ADME, and toxicokinetics for dermatology drugs, biologics, or devices across multiple species and disease models.

Histopathology assessment and ground sectioning for bone and spine fusion polymers.

Murine sclerotic skin model induced by local repeated injection of bleomycin for evaluation of dermal fibrosis.

Preclinical specialized surgical deployment of vascular stents and medical devices.

Histochemical stain service for acid fast bacteria.

Histochemical stain service using Sudan black for fat detection.

Specialized preparation, staining, and assessment of muscle and nerves, including immunohistochemical assessment of neuromuscular endplates.

Pharmacology and efficacy studies focusing on anti-infective agents.

Histopathology assessment and ground sectioning for bone plates, pins, and screws.

Preclinical animal models using ApoE or other mutant mice fed a high fat diet to investigate the effects of a test article on aortic plaque formation and lipidemia.

Specialized preparation, staining, and assessment of dermal wound healing including skin orientation and scoring of epithelial integrity.

Established and validated model of Passive Heymann Nephritis in rats used for studying glomerular diseases and evaluating therapeutic interventions.

Preclinical model assessing retinal vascular leakage induced by Angiotensin-II.

Rodent preclinical model for Retinopathy of Prematurity in premature infants.

An established and validated anti-Fx1A-Induced Passive Heymann Nephritis (PHN) rat model for studying glomerular diseases and evaluating therapeutic interventions.

GLP central nervous system toxicity studies evaluating biologics, small molecules, and devices.

Comprehensive preclinical contract research surgical services and models in multiple rodent species including rat, mouse, guinea pig, hamster, and gerbil.

Validated and optimized superficial, partial thickness, and full thickness thermal and UV burn models in rodents and pigs including Göttingen minipigs and Red Duroc pigs for evaluating therapeutics, biologics, stem cells, and small molecules.

Immunofluorescence testing and analysis services on research models.

Preclinical surgical modeling studies conducted on multiple rodent and large animal species, ranging from simple procedures to highly complex procedures for drug metabolism, pharmacology, or safety study types.

Preclinical contract toxicology studies focusing on dermal applications for drugs, biologics, and devices.

Preclinical pharmacology services for metabolic disease models including diabetes and obesity.

Specialized administration studies involving direct dosing into the intrathecal, intracerebral, or intraventricular spaces.

Safety pharmacology evaluations including Irwin, respiratory, cardiovascular intravenous irritation, and CNS studies.

Full and partial thickness burn models, including UV light induced burns, for preclinical testing.

Specialized surgical models involving intracranial tumor implantation and localized treatment evaluation.

Preclinical efficacy and pharmacology studies targeting fibrotic disease models.

Preclinical model using Watanabe or WHHL rabbits to study the effects of a test article on blood lipidemia, liver lipidosis, and plaque formation.

Preclinical hypertrophic scarring models for therapeutic evaluation.

Preclinical model using hamsters or guinea pigs fed a high fat diet to develop lipidemia and atherosclerosis for evaluating test articles.

Preclinical surgical wound models for evaluating therapeutics.

Precise stereotaxic administration dosing studies, such as 6OHDA for Parkinson's disease models.

Rabbit VX2 tumor models used for evaluating tumor ablation technologies and treatments.

Surgical pharmacology models targeting gastrointestinal and cardiothoracic systems.

Diabetic ulcer and wound models for testing therapeutic efficacy in impaired healing conditions.

Investigative pharmacology studies for novel stem cell therapies and nanoparticle delivery systems.

Customized development, verification, and validation of IHC staining methods.

Rodent neonatal model for pulmonary fibrosis and inflammation induced by a hyperoxygenated environment.

A robust and validated murine model of psoriasis induced by dermal application of imiquimod, an immune modifying toll-like receptor agonist, used for preclinical drug screening and testing.

Specialized preclinical testing and pharmacology studies involving botulinum toxin.

Quantitative histomorphometry and digital image analysis services.

Optimized and validated immune-mediated animal models suitable for the assessment of allergic and autoimmune diseases.

Tissue whole mount preparation combined with immunohistochemistry or immunofluorescence.

Preclinical otic pharmacology studies for inner and middle ear therapeutics.

Pharmacology capabilities across a spectrum of indications for companion and farm animals, fine-tuned to meet specific scientific investigation requirements.

Access to fixed and frozen human, primate, and animal tissues from a comprehensive tissue bank.

Specialized in situ hybridization and human Y chromosome staining procedures.