Class Biologically Clean
Class Biologically Clean, Ltd. (CBC) is a leading manufacturer of high-quality flexible film isolators, clean rooms, containment units, and accessories for use in animal research, pharmaceutical production, and bio/pharmaceutical industries. Established in 1978 and based in Madison, Wisconsin, CBC focuses on creating durable, customizable, and reliable systems that protect both research integrity and personnel safety. Their products include flexible film isolators, semi-rigid isolators, cleanrooms, bio-containment chambers, and decontamination chambers, all designed with strict quality control and innovative features to meet the needs of top research institutions and pharmaceutical companies worldwide. CBC also offers specialized systems such as germ-free breeder isolators, quad isolator systems, HEPA isolator systems, and containment units for highly pathogenic organisms, with options for positive or negative pressure environments. Their products are constructed with almost indestructible polyurethane material, featuring CBC's original lap-seam sealing process to prevent contamination and ensure durability. The company provides accessories like transfer ports, HEPA filters, sterilizing cylinders, and glove port extensions to maintain controlled environments. CBC's systems are designed to be radiated if required, and they emphasize quality control with serial number traceability for all canopies and components. Their systems are suitable for research, testing, production, and quarantine applications, with a focus on protecting both research and researchers.
Industries
Nr. of Employees
small (1-50)
Class Biologically Clean
Products
Flexible-film isolator systems (multiple form factors)
Modular flexible-film isolator systems for gnotobiotic and containment research available in multiple configurations and sizes, with options for positive- or negative-pressure operation and accessory ecosystems.
Semi-rigid isolator systems
Semi-rigid isolators constructed with durable polypropylene or stainless-steel components with expandable glove panels and options for internal lighting and shelving.
Softwall cleanroom and containment chambers
Positive- or negative-pressure softwall cleanroom chambers for research or small-scale production provided as fully enclosed free-standing environments with HEPA/ULPA filtration and resealable assembly methods.
Production-grade isolators for compounding and aseptic tasks
Isolators designed for small-scale production tasks with turbulent-flow designs, bag-in/bag-out interfaces, internal drains and VFD-controlled blowers for automated pressure maintenance.
VHP-compatible isolator systems
Isolator systems designed or equipped for vapor-phase hydrogen peroxide sterilization cycles to enable rapid turnaround of containment environments.
HEPA/ULPA filter cartridges and precut media
Round and square HEPA/ULPA filter cartridges in multiple diameters and lengths, plus precut filter media rolls for use in filters and sterilizing cylinders.
Flexible-film isolator systems (multiple form factors)
Modular flexible-film isolator systems for gnotobiotic and containment research available in multiple configurations and sizes, with options for positive- or negative-pressure operation and accessory ecosystems.
Semi-rigid isolator systems
Semi-rigid isolators constructed with durable polypropylene or stainless-steel components with expandable glove panels and options for internal lighting and shelving.
Softwall cleanroom and containment chambers
Positive- or negative-pressure softwall cleanroom chambers for research or small-scale production provided as fully enclosed free-standing environments with HEPA/ULPA filtration and resealable assembly methods.
Production-grade isolators for compounding and aseptic tasks
Isolators designed for small-scale production tasks with turbulent-flow designs, bag-in/bag-out interfaces, internal drains and VFD-controlled blowers for automated pressure maintenance.
VHP-compatible isolator systems
Isolator systems designed or equipped for vapor-phase hydrogen peroxide sterilization cycles to enable rapid turnaround of containment environments.
HEPA/ULPA filter cartridges and precut media
Round and square HEPA/ULPA filter cartridges in multiple diameters and lengths, plus precut filter media rolls for use in filters and sterilizing cylinders.
Services
Custom design and manufacture of flexible-film and semi-rigid isolator canopies and assemblies to specified dimensions, port layouts and pressure modes; includes replacement canopies and production-grade feature integration.
Pre-configured starter-lab packages bundling isolator systems with hardware, filtration, sterilizing cylinders and accessories to accelerate lab setup and ensure component compatibility.
Provision of ethylene oxide sterilization and preparation of sterilized shipper sleeves and components, plus integration of sterilization indicators and labeling for sterile shipping and use.
Supply of atomizer, compressor and cart systems sized for isolator-scale decontamination and provision of standalone decontamination chambers for small laboratory equipment.
Supply chain and distribution for isolator accessories and consumables including glove materials, transfer sleeves, port caps, clamps, filter media, tapes, bands, stoppers, cage racks and repair kits.
Integration and installation of continuous monitoring systems for pressure, airflow, temperature and humidity with control logic and alarm/readout options to maintain environmental setpoints.
Custom design and manufacture of flexible-film and semi-rigid isolator canopies and assemblies to specified dimensions, port layouts and pressure modes; includes replacement canopies and production-grade feature integration.
Pre-configured starter-lab packages bundling isolator systems with hardware, filtration, sterilizing cylinders and accessories to accelerate lab setup and ensure component compatibility.
Provision of ethylene oxide sterilization and preparation of sterilized shipper sleeves and components, plus integration of sterilization indicators and labeling for sterile shipping and use.
Supply of atomizer, compressor and cart systems sized for isolator-scale decontamination and provision of standalone decontamination chambers for small laboratory equipment.
Supply chain and distribution for isolator accessories and consumables including glove materials, transfer sleeves, port caps, clamps, filter media, tapes, bands, stoppers, cage racks and repair kits.
Integration and installation of continuous monitoring systems for pressure, airflow, temperature and humidity with control logic and alarm/readout options to maintain environmental setpoints.
Expertise Areas
- Flexible-film softwall isolator and cleanroom engineering
- Semi-rigid isolator and enclosure engineering
- Containment design for high-risk biological agents and potent compounds
- Airflow engineering and filtration system design for isolators and cleanrooms
Key Technologies
- Flexible-film softwall isolators
- Semi-rigid isolator systems
- Softwall cleanroom chambers
- HEPA and ULPA filtration cartridges and media
News & Updates
CBC flexible film isolators are featured in a PBS video about microbiome research and its importance in health and disease.
The University of Chicago's Gnotobiotic Research Animal Facility (GRAF) team was recognized for their innovative use of CBC isolators.
An article in Lab Animal discusses the rising demand for germ-free and gnotobiotic animals and the role of CBC's products in supporting this growth.
University of Wisconsin-Madison News reports on research involving CBC isolators and the microbiome's influence on health.
University of Wisconsin Biochemistry News highlights research on the microbiome and its role in insulin regulation and metabolic diseases, supported by CBC isolator systems.
Winner of the 2017 ALN TurnKey Team of the Year Award
Recognition for the Gnotobiotic Research Animal Facility at the University of Chicago for their innovative use of CBC products.
CBC flexible film isolators are featured in a PBS video about microbiome research and its importance in health and disease.
The University of Chicago's Gnotobiotic Research Animal Facility (GRAF) team was recognized for their innovative use of CBC isolators.
An article in Lab Animal discusses the rising demand for germ-free and gnotobiotic animals and the role of CBC's products in supporting this growth.
University of Wisconsin-Madison News reports on research involving CBC isolators and the microbiome's influence on health.
University of Wisconsin Biochemistry News highlights research on the microbiome and its role in insulin regulation and metabolic diseases, supported by CBC isolator systems.
Winner of the 2017 ALN TurnKey Team of the Year Award
Recognition for the Gnotobiotic Research Animal Facility at the University of Chicago for their innovative use of CBC products.