Biological Mimetics
Privately held biomedical company (founded 1996) combining computational biology and engineering to develop vaccines and point-of-care diagnostics. Platforms described include bioinformatics-driven epitope refocusing for immunogen design, UVC-based pathogen inactivation for vaccine production, and a power-free microfluidic chip integrating isothermal amplification and CRISPR detection for low-resource diagnostics. The company participates in IND-enabling work, sponsored research, and collaborative projects with academic and government partners.
Industries
Nr. of Employees
small (1-50)
Biological Mimetics
Frederick, Maryland, United States, North America
Patents
Irradiation-inactivated poliovirus, compositions including the same, and methods of preparation
US-12042533-B2
View Details
Irradiation-inactivated poliovirus, compositions including the same, and methods of preparation
US-12042533-B2
View DetailsProducts
Inactivated vaccine candidates produced via metal-peptide assisted UVC inactivation
Vaccine projects using a metal-peptide complexation step followed by UVC irradiation to generate inactivated vaccine material for preclinical testing (IND-enabling scope referenced).
Acinetobacter and MRSA whole-cell vaccine candidates
Whole-cell and biofilm-derived immunogens developed and tested in preclinical models targeting antibiotic-resistant bacterial pathogens.
Power-free FAST diagnostic chip for nucleic acid detection
Disposable, multi-chamber microfluidic device that enables pipette-free sample processing, isothermal amplification, and CRISPR-mediated detection with optical readout and computer-vision classification.
Rapid bacterial identification and opioid drug testing diagnostics (development projects)
Diagnostic projects aimed at rapid identification of bacterial infections (ellipsometry/LSPR-based) and sensitive in-clinic testing for opioids and other drugs to inform clinical decisions.
FAST
A convenient multi-chambered diagnostic tool pre-loaded with reaction components for simple, instrument-free step-wise performance of CRISPR diagnostics. Integrates isothermal RPA amplification and CRISPR cleavage for sensitive nucleic acid detection, suitable for low-income countries.
FAST (Funnel-adapted sensing tube)
A multi-chambered device that simplifies genotype-specific diagnostics, adapted for multiple pathogens for instrument-free electricity-free diagnostics. It is a simple, portable, and low-cost microfluidic system developed as an integrated, power-free, and pipette-free biosensor for viral nucleic acids.
Inactivated vaccine candidates produced via metal-peptide assisted UVC inactivation
Vaccine projects using a metal-peptide complexation step followed by UVC irradiation to generate inactivated vaccine material for preclinical testing (IND-enabling scope referenced).
Acinetobacter and MRSA whole-cell vaccine candidates
Whole-cell and biofilm-derived immunogens developed and tested in preclinical models targeting antibiotic-resistant bacterial pathogens.
Power-free FAST diagnostic chip for nucleic acid detection
Disposable, multi-chamber microfluidic device that enables pipette-free sample processing, isothermal amplification, and CRISPR-mediated detection with optical readout and computer-vision classification.
Rapid bacterial identification and opioid drug testing diagnostics (development projects)
Diagnostic projects aimed at rapid identification of bacterial infections (ellipsometry/LSPR-based) and sensitive in-clinic testing for opioids and other drugs to inform clinical decisions.
FAST
A convenient multi-chambered diagnostic tool pre-loaded with reaction components for simple, instrument-free step-wise performance of CRISPR diagnostics. Integrates isothermal RPA amplification and CRISPR cleavage for sensitive nucleic acid detection, suitable for low-income countries.
FAST (Funnel-adapted sensing tube)
A multi-chambered device that simplifies genotype-specific diagnostics, adapted for multiple pathogens for instrument-free electricity-free diagnostics. It is a simple, portable, and low-cost microfluidic system developed as an integrated, power-free, and pipette-free biosensor for viral nucleic acids.
Services
Partnerships with academic, government, and industry sponsors to advance platform technologies, run funded research projects, and support grant deliverables.
Partnerships with academic, government, and industry sponsors to advance platform technologies, run funded research projects, and support grant deliverables.
Expertise Areas
- Vaccine development and preclinical IND-enabling studies
- Immunogen design using bioinformatics and immune refocusing
- Point-of-care nucleic acid diagnostics
- Microfluidic device design and disposable chip fabrication
Key Technologies
- CRISPR-based molecular diagnostics (Cas12/Cas13 approaches)
- Recombinase polymerase amplification (RPA)
- Multi-chamber power-free microfluidics
- UVC pathogen inactivation
News & Updates
Peer-reviewed Lab on a Chip publication describing the FAST microfluidic system, isothermal RPA-CRISPR workflow, use of PVA sacrificial core fabrication, and a computer-vision algorithm for result classification.
PLoS ONE publication reporting a radiation-inactivated Sabin-based polio vaccine candidate.
Multiple peer-reviewed articles and conference publications describing microfluidic diagnostics, nanoparticle-enhanced biosensing, and vaccine candidate studies listed on the publications page.
Patents and filings related to immunogenic influenza, human rhinovirus, and other immunogenic compositions are listed among the company's publications and patent references.
Peer-reviewed Lab on a Chip publication describing the FAST microfluidic system, isothermal RPA-CRISPR workflow, use of PVA sacrificial core fabrication, and a computer-vision algorithm for result classification.
PLoS ONE publication reporting a radiation-inactivated Sabin-based polio vaccine candidate.
Multiple peer-reviewed articles and conference publications describing microfluidic diagnostics, nanoparticle-enhanced biosensing, and vaccine candidate studies listed on the publications page.
Patents and filings related to immunogenic influenza, human rhinovirus, and other immunogenic compositions are listed among the company's publications and patent references.