BIA Separations

Platform methods and workflows for purification of clinical-quality bacteriophages, intended to support downstream chromatographic polishing and QC-ready outputs.

Open-channel CIM monolithic chromatography columns offering high flow rate and high binding capacity for bioprocess purification.

Monolithic chromatography column with SO3 strong cation exchange chemistry.

Monolithic chromatography screening plates featuring QA HR chemistry.

Parallel screening with 8-column strips for automated systems, designed for parallel chromatographic condition screening.

Miniaturized, pre-packed monolithic column intended for automated and parallel screening of chromatography conditions using robotic liquid handling workstations. PrimaS chemistry is used for purification of single-stranded RNA at ambient temperature.

CIM® Octa PrimaT monolithic chromatography column offering AAV binding at neutral or closer to neutral pH values and separation of AAV subpopulations.

Monolithic chromatography unit for analytical and preparative separations with high batch-to-batch reproducibility.

A cGMP compliant monolithic chromatography column featuring Quaternary Amine chemistry and 1.3 µm channels, designed for scalable high-resolution purification of complex biological samples such as large proteins, viruses, and virus-like particles.

CIMmultus PrimaT 40 mL cGMP Compliant Monolithic Column features a 2 µm channel size and multimodal ligand chemistry combining anion exchange, hydrogen bonding, and metal affinity for scalable high-resolution purification.

A 4 mL monolithic chromatography column featuring DEAE weak anion exchanger chemistry and 1.3 µm channels, designed for scalable high-resolution purification of complex biological samples such as large proteins, viruses, and virus-like particles.

Cation exchange monolithic column designed for the capture step of AAV purification, operating at acidic pH to remove host cell impurities and concentrate AAV.

Affinity chromatography monolithic column for mRNA and oligonucleotide purification.

A reusable chromatography device with an 8 mL bed volume featuring a single-piece monolithic stationary phase, designed for fast and efficient capture and purification of messenger RNA with a polyadenylated tail.

CIMmultus Oligo dT18 4 mL cGMP Compliant Monolithic Column with C12 Linker featuring 2 um channels for fast and efficient capture and purification of messenger RNA with a poly adenylated tail.

A cGMP compliant monolithic chromatography column featuring a hydroxyl (OH) chemistry and an 8000 mL bed volume, designed for scalable high-resolution purification of proteins, viral particles, and other biomolecules.

Reusable chromatography device for scalable high-resolution purification of complex biological samples using hydrogen bonding as the dominant force of retention.

A monolithic column utilizing a Selective Hydrophobic Interaction Chromatography approach for polishing plasmid DNA, effectively removing open-circular pDNA and genomic DNA.

Reversed phase chromatography monolithic column from the CIMmultus product line.

Activated chemistry chromatography monolithic column for ligand immobilization.

Activated chemistry chromatography monolithic column for ligand immobilization.

Affinity chromatography monolithic column for antibody purification.

Anion exchange chromatography monolith designed to remove process-related impurities derived from host cells during plasmid DNA purification.

Standard format 96-well plate prefilled with DEAE weak anion exchange monolithic chromatographic media, intended for high-throughput screening and process development.

Standard format 24-well plate prefilled with strong anion exchanger quaternary amine monolithic chromatographic media intended for diagnostic, screening, and high-throughput process development purposes.

CIM® QA HR 0.2 mL Monolithic 96-Well Plate is a powerful tool designed for screening of multiple process conditions in parallel, enabling quick process development and transfer to preparative scale.

Strong anion exchange monolithic well plate designed for capture and polishing steps.

Strong anion exchange monolithic well plate designed for high-resolution capture and polishing of target biomolecules.

Monolithic 96-well plates designed for design of experiments and downstream process optimisation for lentiviral applications.

0.05 mL monolithic 96-well plate with 2 um channel size featuring SO3 strong cation exchanger chemistry.

0.05 mL monolithic 96-well plate with 2 um channel size featuring SO3 strong cation exchanger chemistry.

1.0 mL monolithic 24-well plate with 2 um channel size featuring SO3 strong cation exchanger chemistry.

0.05 mL monolithic 96-well plate with 2 μm channel size utilizing C4 high ligand density chemistry.

0.05 mL monolithic 96-well plate with 2 μm channel size utilizing C4 high ligand density chemistry.

1.0 mL monolithic 24-well plate with 2 μm channel size utilizing C4 high ligand density chemistry.

Hydrophilic chromatography monolithic well plate featuring 6 µm channels for applications such as LNP and bacteriophage purification.

0.05 mL volume monolithic 96-well plate with 2 µm channel size, featuring CIM® OH chemistry.

Monolithic 96-well plate utilizing strongly hydrophobic polystyrene divinylbenzene (SDVB) for reversed phase purification and high-throughput screening of nucleic acids and biomolecules.

Monolithic 24-well plate utilizing strongly hydrophobic polystyrene divinylbenzene (SDVB) for reversed phase purification and high-throughput screening of nucleic acids and biomolecules.

Reversed-phase chromatography monolithic well plate designed for applications such as mRNA polishing.

Affinity chromatography monolithic well plate with C12 linker and Oligo dT18 for mRNA purification.

Affinity chromatography monolithic well plate with C12 linker and Oligo dT18 for mRNA purification.

Affinity chromatography monolithic well plate with C6 linker and Oligo dT18 for mRNA purification.

Affinity chromatography monolithic well plate functionalized with r-Protein G LLD.

Affinity chromatography monolithic well plate functionalized with r-Protein G.

An analytical column designed for plasmid DNA analysis, enabling the quantification of all pDNA isoforms and monitoring of degradation products and impurity removal.

A comprehensive solution for USP monitoring, designed for the efficient enrichment and separation of AAV vectors using a tandem 2D chromatography setup.

Platform tailored for LNP modalities.

Analytical column designed for fast and efficient HPLC monitoring and quantitation of messenger RNA (mRNA) with a poly-adenylated tail.

Analytical column designed for fast and efficient HPLC monitoring and quantitation of messenger RNA (mRNA) with a poly-adenylated tail.

Analytical column designed for fast and efficient HPLC monitoring and quantitation of messenger RNA (mRNA) with a poly-adenylated tail.

Pre-packed chromatographic monolithic product with a multimodal chromatography ligand combining hydrogen bonding and weak anion exchange, offering high reproducibility between batches.

Process Packs support the development and scale-up of large molecule purification, coming with recommended CIMmultus columns and detailed process instructions.

A reusable cGMP compliant monolithic chromatography column featuring a strong anion exchanger quaternary amine chemistry, designed for high-resolution purification of complex biological samples and AAV empty-full capsid separation.

Multimodal weak anion exchanging chromatography monolith plate designed for high-throughput screening and purification of nucleic acids such as RNA, DNA, and proteins from complex samples.

High-performance chromatography devices designed to rapidly fractionate complex biological samples via size exclusion. Packed in SUS-316 stainless steel housings for easy connection to any chromatography system.

Analytical monolithic column designed for high-resolution separation of AAV capsids.

Purification process packs designed to separate and purify plasmid DNA efficiently.

Chromatography monoliths in multi-well plate format compatible with high throughput and automation solutions.

Cation exchange monolithic well plate designed for capture and purification applications such as AAV.

CIMmultus® Oligo dT18 (C6 Linker) column is designed for the effective isolation of messenger RNA while eliminating other elements from the in-vitro transcription mixture.

Analytical monolithic chromatography columns providing accurate and consistent data to support quality control and compliance.

Analytical columns employing a strong anion exchanger ligand designed for rapid and reliable HPLC monitoring and quantitation of Adeno-associated virus (AAV) samples, effectively separating empty viral capsids, aggregated and damaged particles, and genome-containing virus vectors.

A 96-well monolithic chromatography screening plate featuring PrimaS multimodal chemistry and a 2 µm channel size, designed for high-throughput applications such as mRNA purification and chromatographic condition screening.

Customized monolith development and preparation service tailored to enhance purification efficiency for research and GMP-regulated manufacturing.

CIMac PrimaS Analytical Columns are designed for high-performance chromatography, offering unique selectivity for the analysis and purification of mRNA using a multimodal ligand.

High-throughput condition screening in 24- and 96-well format for automation-compatible chromatographic condition screening.

Comprehensive upstream and downstream process development services for AAV, offering transfection-based methods, scale-up, serotype-agnostic capture, and advanced polishing methods.

Comprehensive downstream solutions and feasibility studies for lentivirus biomanufacturing development, offering single-step or full processes with over 70% infectious recovery.

CIMac SDVB analytical column utilizing strongly hydrophobic styrene divinylbenzene (SDVB) as the reversed-phase chromatography ligand for high-throughput and high-resolution HPLC analytics.

Screening solution designed to speed up development processes and optimize workflows.