BIA Separations
Sartorius BIA Separations is a leading developer of monolith technology and the exclusive producer of CIM Convective Interaction Media® chromatographic columns for the production, purification, and analysis of large biomolecules. The company specializes in innovative solutions for gene therapy, vaccines, and bioprocessing, with a focus on high-quality chromatography materials and methods to accelerate development, improve product quality, and reduce costs. With a history of over 20 years of innovation, Sartorius BIA Separations is committed to excellence, customer service, ecological sustainability, and social responsibility, operating from its headquarters in Ajdovščina, Slovenia, and maintaining international sales and distribution offices.
Industries
Nr. of Employees
medium (51-250)
BIA Separations
Ajdovscina, Ajdovscina Commune, Slovenia, Europe
Products
Preparative monolithic chromatography columns
Tubular and composite-format monolithic columns for preparative-scale purification of large biomolecules and viral vectors, designed for high flow rates and reduced dispersion.
Analytical monolithic columns
Analytical-scale monolithic columns and chemistries intended for characterization and QC of viral vectors, nucleic acids and other large biomolecules.
At-line analytical platforms for nucleic acids and viral analytics
Integrated hardware and software platforms for at-line chromatographic monitoring of pDNA, mRNA, AAV and LNP process samples, including prevalidated methods and inline sensors.
Monolithic well plates and small-scale screening columns
High-throughput monolithic 96-well plates and miniaturized multi-column units for buffer and condition screening prior to scale-up.
In-line lysis systems
Hardware systems for continuous or in-line cell lysis to improve upstream-to-downstream integration and reduce manual handling during harvest processing.
Exosome process development solution
Service and platform workflows aimed at enabling industrial-scale purification and manufacture of therapeutic extracellular vesicles/exosomes.
Preparative monolithic chromatography columns
Tubular and composite-format monolithic columns for preparative-scale purification of large biomolecules and viral vectors, designed for high flow rates and reduced dispersion.
Analytical monolithic columns
Analytical-scale monolithic columns and chemistries intended for characterization and QC of viral vectors, nucleic acids and other large biomolecules.
At-line analytical platforms for nucleic acids and viral analytics
Integrated hardware and software platforms for at-line chromatographic monitoring of pDNA, mRNA, AAV and LNP process samples, including prevalidated methods and inline sensors.
Monolithic well plates and small-scale screening columns
High-throughput monolithic 96-well plates and miniaturized multi-column units for buffer and condition screening prior to scale-up.
In-line lysis systems
Hardware systems for continuous or in-line cell lysis to improve upstream-to-downstream integration and reduce manual handling during harvest processing.
Exosome process development solution
Service and platform workflows aimed at enabling industrial-scale purification and manufacture of therapeutic extracellular vesicles/exosomes.
Services
Biomanufacturing development services
Technical guidance, process development and training to support purification and analytical method development across development and scale-up.
Analytics development services
Development and validation of chromatographic analytical methods and support for at-line monitoring implementation.
Process development for viruses, VLPs, exosomes and nanoparticles
Process optimization and method development for viral vectors, virus-like particles, extracellular vesicles/exosomes and nanoparticle purification using monolithic chromatography and orthogonal analytics.
Nucleic acids process development
Development services for plasmid DNA and mRNA production and purification workflows including screening and scale-up guidance.
Custom monolith development and manufacture
Bespoke design and manufacturing of monolithic chromatography media with tailored ligands and formats for specific separation requirements.
Technical support and training
Customer support, training courses and symposiums focused on adoption and optimization of monolithic chromatography and analytical platforms.
Biomanufacturing development services
Technical guidance, process development and training to support purification and analytical method development across development and scale-up.
Analytics development services
Development and validation of chromatographic analytical methods and support for at-line monitoring implementation.
Process development for viruses, VLPs, exosomes and nanoparticles
Process optimization and method development for viral vectors, virus-like particles, extracellular vesicles/exosomes and nanoparticle purification using monolithic chromatography and orthogonal analytics.
Nucleic acids process development
Development services for plasmid DNA and mRNA production and purification workflows including screening and scale-up guidance.
Custom monolith development and manufacture
Bespoke design and manufacturing of monolithic chromatography media with tailored ligands and formats for specific separation requirements.
Technical support and training
Customer support, training courses and symposiums focused on adoption and optimization of monolithic chromatography and analytical platforms.
Expertise Areas
- Monolithic chromatography media design and manufacture
- Downstream process development for viral vectors, nucleic acids, LNPs and nanoparticles
- Analytical method development and at-line process analytics (PAT)
- Process scale-up strategies for chromatographic separations
Key Technologies
- Monolithic convective chromatography
- Convective mass transport
- Anion and cation exchange chromatography
- Multimodal chromatography chemistries