Azitra, Inc.


Azitra is a clinical-stage precision dermatology company that leverages its extensive knowledge of genetic engineering, proteomics, and the skin microbiome to create and develop novel products for the treatment of skin diseases. The company focuses on developing genetically engineered bacteria and proteins to treat adverse skin conditions and diseases, utilizing microbial and protein engineering, artificial intelligence, and a proprietary microbial library. Azitra's initial focus is on engineered strains of Staphylococcus epidermidis for dermatologic therapies, with a pipeline including candidates ATR-12, ATR-04, and ATR-01 for conditions like Netherton syndrome, EGFR inhibitor-associated rash, and ichthyosis vulgaris.

Industries

alternative-medicine
biotechnology
consumer-goods
health-care

Nr. of Employees

small (1-50)

Azitra, Inc.

Branford, Connecticut, United States, North America


Patents

Methods and compositions for treating inflammatory skin disease with recombinant microorganisms

US-12208124-B2

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Therapeutic treatment of skin disease with recombinant commensal skin microorganisms

US-12036248-B2

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Methods and compositions for treating skin disease with recombinant microorganisms

US-11850267-B2

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Compositions and methods for treatment of Netherton Syndrome with LEKTI expressing recombinant microbes

US-11773154-B2

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Auxotrophic strains of staphylococcus bacterium

US-11041217-B2

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Therapeutic treatment of skin disease with recombinant commensal skin microorganisms

US-10702558-B2

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Products

Engineered auxotrophic Staphylococcus epidermidis secreting LEKTI for Netherton syndrome (clinical-stage candidate)

A live biotherapeutic candidate based on an engineered auxotrophic skin commensal designed to secrete the LEKTI protein to address the molecular deficiency underlying Netherton syndrome; prepared for first-in-human clinical evaluation.

Auxotrophic Staphylococcus epidermidis for EGFR inhibitor-associated rash (development candidate)

A live biotherapeutic candidate using an engineered auxotrophic skin commensal aimed at preventing or treating rash associated with epidermal growth factor receptor (EGFR) inhibitor therapy.

Recombinant filaggrin protein therapeutic for ichthyosis vulgaris (development candidate)

A protein therapeutic candidate based on filaggrin intended to address barrier defects in ichthyosis vulgaris.

Expertise Areas

  • Precision dermatology
  • Microbiome therapeutics
  • Live biotherapeutic product development
  • Microbial genetic engineering
  • Show More (4)

Key Technologies

  • Engineered commensal bacteria for topical delivery
  • Auxotrophy-based biocontainment
  • Secretion of therapeutic proteins from microbes
  • CRISPRi and bacterial transcriptomics
  • Show More (4)

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