AUM BioTech
AUM Biotech is dedicated to revolutionizing gene silencing with its innovative antisense technology platform. Their mission is to provide highly specific, efficient, and easy-to-use RNA silencing tools that work across a wide range of cell types and organisms, including in vivo applications. Their vision is to accelerate biomedical research and therapeutic development through advanced nucleic acid platform technologies, including self-delivering antisense oligonucleotides for mRNA, miRNA, lncRNA, and viral RNA knockdown, leveraging AI-driven design and proprietary chemical modifications.
Industries
Nr. of Employees
small (1-50)
AUM BioTech
3675 Market Street, Suite 200, Philadelphia, PA 19104, USA
Products
Self-delivering ASOs for mRNA knockdown
Short gapmer antisense oligonucleotides designed for RNase H-mediated degradation of mRNA with chemical modifications that enable cellular uptake without transfection reagents.
Antisense reagents for miRNA inhibition
Antagomir-style oligonucleotides designed to bind and inhibit microRNAs via steric blocking and/or degradation, compatible with direct addition to cultures or tissue slices.
Antisense reagents for lncRNA knockdown
Oligonucleotides optimized for nuclear uptake and RNase H-mediated degradation or steric blockade of long non-coding RNAs, enabling functional studies of nuclear-retained transcripts.
Antisense reagents for viral RNA targeting
Oligonucleotides tailored to conserved and essential regions of viral genomes or transcripts to inhibit replication via RNase H degradation and/or steric blocking.
Exon-skipping and steric-blocking antisense oligonucleotides
ASOs designed to redirect splicing (exon skipping) or block RNA function by steric hindrance without inducing cleavage, suitable for splice-modulation studies and functional blockade.
Transfection-optimized, cost-effective ASOs for screening
Budget-oriented antisense reagents formulated for use with standard transfection protocols suitable for high-throughput screening and routine laboratory applications.
Self-delivering ASOs for mRNA knockdown
Short gapmer antisense oligonucleotides designed for RNase H-mediated degradation of mRNA with chemical modifications that enable cellular uptake without transfection reagents.
Antisense reagents for miRNA inhibition
Antagomir-style oligonucleotides designed to bind and inhibit microRNAs via steric blocking and/or degradation, compatible with direct addition to cultures or tissue slices.
Antisense reagents for lncRNA knockdown
Oligonucleotides optimized for nuclear uptake and RNase H-mediated degradation or steric blockade of long non-coding RNAs, enabling functional studies of nuclear-retained transcripts.
Antisense reagents for viral RNA targeting
Oligonucleotides tailored to conserved and essential regions of viral genomes or transcripts to inhibit replication via RNase H degradation and/or steric blocking.
Exon-skipping and steric-blocking antisense oligonucleotides
ASOs designed to redirect splicing (exon skipping) or block RNA function by steric hindrance without inducing cleavage, suitable for splice-modulation studies and functional blockade.
Transfection-optimized, cost-effective ASOs for screening
Budget-oriented antisense reagents formulated for use with standard transfection protocols suitable for high-throughput screening and routine laboratory applications.
Services
Design of optimized antisense sequences using computational algorithms and delivery of research-grade oligonucleotides (lyophilized or in solution) for research applications.
Provision of detailed in vitro and in vivo protocols, troubleshooting guidance, dose optimization advice and scientific consultation to support experimental design and implementation.
Design of optimized antisense sequences using computational algorithms and delivery of research-grade oligonucleotides (lyophilized or in solution) for research applications.
Provision of detailed in vitro and in vivo protocols, troubleshooting guidance, dose optimization advice and scientific consultation to support experimental design and implementation.
Expertise Areas
- Antisense oligonucleotide development
- RNA-targeted modulation (mRNA, miRNA, lncRNA, viral RNA)
- AI-driven oligonucleotide design and off-target prediction
- In vitro and in vivo gene-silencing experimental workflows
Key Technologies
- Antisense oligonucleotides (gapmer architecture)
- Phosphorothioate backbone chemistry
- Advanced sugar and backbone modifications for stability
- RNase H1-mediated RNA cleavage