Atoxigen

ADME Tox model of zebrafish in the embryo-larvae stage used for predictive toxicology testing.

In vitro assays offered by Atoxigen to detect endocrine disruptors present in plastics, cosmetics, pesticides, pharmaceuticals, consumer products, and packaging.

Evaluation of medical devices according to ISO 10993 standards using in vitro and in vivo assays, including cytotoxicity, genotoxicity, and hemocompatibility testing.

In vitro mammalian cell micronucleus test conducted under GLP conditions conforming to OECD 487.

Predictive toxicology and ADME screening services using zebrafish models.

Ethically compliant ADMET testing services tailored for early stages of R&D up to GLP studies.

A unique combination of analytical and biological expertise for evaluating primary packaging, dyes, adhesives, and varnishes to support cosmetic product safety and compliance.

Systemic toxicity evaluation services provided in partnership, following ISO 10993-11.

Testing and assay services focusing on endocrine disruptors and toxicity by additivity, synergetic effect or supra additivity in leachable products.

Genotoxicity testing services for medical devices compliant with ISO 10993-3.

General toxicology testing services.

In vitro cytotoxicity testing services for medical devices compliant with ISO 10993-5.

Toxicity testing and detection of contents and containers interactions focusing on endocrine disrupting chemicals like BPA, parabens, and phthalates found in packaging for cosmetics, food, and beverages.

Performance-based test guideline for stably transfected transactivation in vitro assays to detect oestrogen receptors agonists and antagonists.

In vitro test method for measuring changes in the production of testosterone and 17beta-oestradiol in the H295R cell line.

Stably transfected transactivation in vitro assay to detect androgen receptor agonists and antagonists.

Toxicology testing services including comet assay, Ames test (OECD 471), micronucleus test (OECD 487), and skin/eye irritation standards (OECD 432, OECD 439, OECD 431).

Customised R&D service for evaluating the efficacy of cosmetic products using genomics, reconstructed epidermis models, and various biological assays.

Specialized assays targeting Triiodothyronine (TR), Obesogens (PPAR), and Dioxins/PCBs (AhR).

Ethically compliant reconstructed 3D model testing services for cosmetic and toxicology evaluation.

Assays using in vitro 3D models including micronucleus test, comet assay, efficiency effects, cosmetogenomics, immune defense biomarkers, anti-pollution, and anti-inflammatory testing.

Comet assay service for genotoxicity screening.

Ex vivo solutions for anti-aging, anti-microbial peptides, hair growth, cosmetogenomics, and sensitization studies.

Screening services for detecting Dioxin-like aryl hydrocarbon receptor (AhR) substances.

In vivo irritation and skin sensitization testing services in partnership, compliant with ISO 10993-10.

Ocular irritation testing service using methods such as Agarose neutral red release, Het-cam OPI, and SkinEthic model on reconstructed cornea epithelium.

Cytotoxicity testing services for safety assessment.

Expert consulting services in toxicology and safety assessment.

In vitro mammalian chromosomal aberration test conforming to OECD 473.

Bacterial reverse mutation assay (Ames test) for genotoxicity testing conforming to OECD 471.

Specialized skin disease model testing services for early research and regular GLP studies.

Screening services for detecting substances linked to obesity and diabetes.

Hemocompatibility evaluation services for medical devices in accordance with ISO 10993-4.

Evaluation of hair growth and anti hair growth testing service using skin explants and QRTPCR to assess gene expression changes such as FGF7, KRTI5, IGF1R, WNT, beta-catenin, SRD5A1, and BMP-2.

Testing services for local effects after implantation in partnership, compliant with ISO 10993-6.

Skin irritation testing service conforming to OECD 439 guidelines.

Mouse lymphoma assay (MLA) for genotoxicity testing conforming to OECD 476.

Phototoxicity testing service conforming to OECD 432 guidelines.

Skin corrosion testing service conforming to OECD 431 guidelines.

Testing service evaluating the effects of extrinsic environmental factors and solar radiation on skin aging, extracellular matrix degradation, inflammation, and DNA damage.