Angel Medical Systems


Developer of an implantable intracardiac monitoring and patient-alerting system for early detection of acute coronary syndrome (ACS) events. Focus areas include continuous intracardiac electrogram acquisition, machine-learning derived patient-specific ST-shift detection, randomized pivotal clinical trials with independent adjudication, regulatory authorizations for implantable cardiac devices, and payer engagement for coding and reimbursement.

Industries

biopharma
biotechnology
health-care
medical-device

Nr. of Employees

small (1-50)

Angel Medical Systems

Eatontown, NJ (city listed in press releases)


Products

Implantable intracardiac monitoring and alerting system

An implantable monitoring device connected to an active-fixation intracardiac sensing lead that continuously acquires intracardiac electrograms, applies machine-learning derived patient-specific ST-shift detection, stores triggered electrograms for clinician review, and provides internal vibration plus external auditory/visual patient alerts.


Services

Support for physician and facility reimbursement processes including coding guidance, coverage/payment support, and prior authorization assistance.

Onsite and remote clinician education and procedural support covering implantation technique, device programming, follow-up interrogation, and use of device-derived electrogram data in clinical pathways.

Support for randomized pivotal trials including site oversight, independent ECG and angiographic core labs, clinical events adjudication, and adaptive statistical monitoring.

Analysis of post-approval device performance metrics, preparation of scientific presentations and publications, and evidence-generation to inform clinical adoption.

Expertise Areas

  • Implantable intracardiac monitoring and patient alerting
  • Machine learning for cardiac signal analysis and adaptive thresholding
  • Randomized, multi-center clinical trial design and execution
  • Bayesian adaptive trial design and interim analysis
  • Show More (5)

Key Technologies

  • Intracardiac electrogram (iEGM) monitoring
  • Continuous ST-segment deviation detection
  • Machine learning–based personalized thresholding
  • IS-1 compatible intracardiac sensing lead integration
  • Show More (5)

News & Updates

Presentation/participation at SCAI 2024 scientific meeting.

Attendance/participation at Heart Rhythm 2024 conference.

Exhibit/participation at TCT 2024 conference.

Randomized multicenter trial evaluating an implantable intracardiac monitor with real-time alarms to reduce pre-hospital delay for ACS events; reports on detection-to-presentation time, PPV, and safety.

Multicenter randomized ALERTS trial results showing device safety, analyses of detection-to-presentation times, and expanded analyses of positive predictive value and false-positive rates.

U.S. FDA granted premarket approval for an implantable real-time cardiac monitor indicated to detect ACS events.

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