Longitude Capital


Longitude Capital is a venture capital firm specializing in venture growth investments in biotechnology, medical technology, and health solutions companies. The firm focuses on improving clinical outcomes, enhancing patient quality of life, and reducing the cost of care. Since its inception in 2006, Longitude Capital has raised over $2 billion across six funds, demonstrating a strong track record in sourcing, managing, and exiting investments across various market cycles. The firm employs a balanced portfolio strategy, investing in clinical-stage and commercial-stage companies with clinically de-risked assets and favorable valuations. Longitude Capital leverages its extensive industry network and proprietary research to identify new investment opportunities and utilizes a variety of investment structures to optimize returns for stakeholders.

Longitude Capital

Longitude Capital

2740 Sand Hill Road, 2nd Floor, Menlo Park, CA 94025


What We Do

Longitude Capital works closely with portfolio companies to develop and implement strategic plans, achieve key operating objectives, and build world-class teams.

The firm assists portfolio companies in raising capital and pursuing liquidity opportunities to optimize returns for stakeholders.

Longitude Capital provides operational support to its portfolio companies, helping them achieve technical, clinical, and commercial milestones.


Investment Stage


Portfolio

Focused on nonalcoholic steatohepatitis (NASH) and other liver and metabolic disorders.

#Biotechnology

Developing treatments for Claudin-1 positive (CLDN1+) tumors and organ fibrosis.

#Biotechnology

Developing imaging and therapeutic molecules for the treatment of solid and hematologic cancers.

#Biotechnology

Developing the LOCOcyteTM cell-therapy platform for continuous local dosing of immunotherapeutics.

#Biotechnology

Developing novel therapies for obesity and metabolic diseases discovered by harnessing the biology of aging.

#Biotechnology

Developing a next-generation IVL (intravascular lithotripsy) device for the minimally invasive treatment of narrowed calcified arteries.

#Medical Technology

Developed the Rapid Response EEG™, a novel non-invasive brain monitor.

#Medical Technology

Developing oncolytic immunotherapies for patients with advanced cancer.

#Biotechnology

Provides solutions to transform utilization management for collaborative care journeys.

#Health Solutions

Provides holistic solutions for children with autism and other neurodevelopmental conditions.

#Health Solutions

Focused on the discovery and development of therapies to treat neurodegenerative diseases.

#Biotechnology

Developing new treatments for idiopathic pulmonary fibrosis.

#Biotechnology

Developing therapeutics that promote mitochondrial biogenesis and function.

#Biotechnology

Developing new medicines to treat rare disorders of calcification.

#Biotechnology

Developed a tech-enabled solution to meet the needs of nurses and healthcare provider organizations.

#Health Solutions

Commercializing a modernized Wearable Cardioverter Defibrillator.

#Medical Technology

Developing first-in-class monoclonal antibodies targeting the IL-11 receptor (IL-11R).

#Biotechnology

Developing a pipeline of gene therapies for rare and non-rare monogenic diseases.

#Biotechnology

Commercializing the Vivistim System, a novel vagus nerve stimulation (VNS) therapy.

#Medical Technology

Dedicated to transforming the treatment of rare liver diseases.

#Biotechnology

Developing and marketing a cloud-based SaaS platform for clinicians.

#Health Solutions

Developing next-generation neuro-stimulation devices for pain.

#Medical Technology

Providing a digital platform to identify and manage obsessive-compulsive disorder.

#Health Solutions

Partners with primary care practices to provide clinical and administrative support.

#Health Solutions

Focused on discovering and developing small molecule inhibitors for cancer immunotherapy.

#Biotechnology

Developing pharmaceutical products for the treatment of brain tumors.

#Biotechnology

Developing oral treatments for metabolic disorders.

#Biotechnology

Developing a novel device for treating mitral valve regurgitation.

#Medical Technology

Developing precision therapies for RAS-driven cancers.

#Biotechnology

Creates products to detect microbial contamination in the manufacture of pharmaceuticals.

#Biotechnology

Providing concierge kidney care to delay or prevent the progression of chronic kidney disease.

#Health Solutions

Developing therapies for the treatment of progressive myopia in children.

#Biotechnology

Developing innovative cellular therapies for organ transplantation and severe auto-immune disorders.

#Biotechnology

Focused on developing treatments for immunological and inflammatory diseases.

#Biotechnology

Developing first-in-class therapeutics for common dermatologic conditions.

#Biotechnology

Developing new treatments for patients suffering from serious diseases underserved by current therapies.

#Biotechnology

Delivering comprehensive care to medically frail seniors, resulting in better outcomes at lower cost.

#Health Solutions

Developing and commercializing unique therapies for patient populations in endocrinology, neurology, and gastroenterology.

#Biotechnology

Developing innovative autoimmune therapeutics.

#Biotechnology

Focused on developing a proprietary botulinum toxin complex for the treatment of multiple debilitating medical conditions.

#Biotechnology

Developing oral immunotherapies to treat acute food allergies.

#Biotechnology

Focused on delivering innovative therapies to patients with kidney disease.

#Biotechnology

Focused on the commercialization and development of therapeutics to improve cardiovascular health.

#Biotechnology

Developing devices to treat overactive bladder.

#Medical Technology

Intended to discover, design and develop novel biologics, protein and peptide therapeutics.

#Biotechnology

Developing innovative therapies for neurological disorders.

#Biotechnology

Developed helical anchor technology for improved endovascular aneurysm repair.

#Medical Technology

Developing implantable devices for the treatment of glaucoma.

#Medical Technology

Developing next-generation immunomodulators with a proprietary High Affinity Ligands of Siglecs (HALOS™) nanotechnology platform to alleviate chronic, non-resolving inflammation.

#Biotechnology

Developing a miniaturized rechargeable implantable neuromodulation technology to treat urinary and fecal dysfunction.

#Medical Technology

Developing endoscopically-delivered devices for the treatment of obesity.

#Medical Technology

Developed and marketed Ofirmev, an intravenous form of acetaminophen for pain management.

#Biotechnology

Markets genomic tests to help cardiologists assess and treat cardiovascular disease.

#Biotechnology

Develops cancer immunotherapies designed to recognize and destroy tumor cells.

#Biotechnology

Developing CVT-301, a potentially transformative therapy for people with Parkinson’s disease.

#Biotechnology

Developing abuse-deterrent pharmaceutical products for chronic pain.

#Biotechnology

Developing pharmaceuticals for patients with severe metabolic and oncologic disorders.

#Biotechnology

Provides liquidity and financing solutions to royalty owners and companies in the global healthcare sector.

#Health Solutions

An orphan drug accelerator focused on identifying and de-risking programs with therapeutic and commercial potential.

#Biotechnology

Developing algorithms as predictive biomarkers for complex medical conditions.

#Biotechnology

Sells a virtually invisible, innovative hearing aid directly to the consumer.

#Medical Technology

Acquires and manages prescription dermatology assets for both cosmetic and medical procedures.

#Biotechnology

Developing oral, low-density, lipoprotein cholesterol (LDL-C) lowering therapies to treat hypercholesterolemia without statins.

#Biotechnology

Developing the Norm™ heart failure management system that enables patients to engage in physician directed self-management of heart failure.

#Medical Technology

Provides cellular services for both the fertility and cellular therapy sectors.

#Health Solutions

Developing the only pharmacologic treatment for infantile jaundice.

#Biotechnology

Developing a portfolio of NLRP3 inhibitors to treat inflammation driven diseases.

#Biotechnology

Developing and marketing specialty pharmaceuticals for a variety of neurological and oncologic conditions.

#Biotechnology

Developing NT-814 for the treatment of common, chronic debilitating female sex-hormone related conditions.

#Biotechnology

Developing a minimally-invasive technology for the treatment of chronic limb-threatening ischemia (CLTI).

#Medical Technology

Focused on the discovery, development and commercialization of next generation immunotoxins called Engineered Toxin Bodies for the treatment of cancer.

#Biotechnology

Developing tolperisone, a novel, patented skeletal muscle relaxant for the treatment of acute, painful muscle spasms without sedation.

#Biotechnology

Developed and markets the System One, a device for home-based nocturnal hemodialysis therapy.

#Medical Technology

Developed the world’s first electronically focusing progressive lens to move automatically between a user’s optimal near and far vision prescriptions.

#Medical Technology

Translating best-in-class gene engineering technologies into CAR T-cell immunotherapies for multiple myeloma, prostate and other cancers.

#Biotechnology

Provides a cloud-based electronic health record platform to connect doctors, patients and data to drive better health.

#Health Solutions

Sold both prescription and non-prescription skin care products.

#Biotechnology

Markets diagnostic assays that help oncologists recommend chemotherapy regimens tailored to patients’ specific tumor genetics.

#Biotechnology

Developing surgical robotics to provide transformative solutions in urology.

#Medical Technology

Developing disposable devices to prevent accidental bowel leakage.

#Medical Technology

Developing adjustable intraocular lenses for cataract surgery.

#Medical Technology

Developing therapeutics for the treatment of hematology and oncology.

#Biotechnology

Developed and marketed energy-based devices for a variety of aesthetic applications.

#Medical Technology

Developing therapies for the treatment of ulcerative colitis.

#Biotechnology

Developing a wearable, non-invasive medical device to reduce blood pressure in hypertensive patients.

#Medical Technology

Developing pan-variant tyrosine kinase inhibitors designed to overcome treatment-resistant cancer.

#Biotechnology

Focused on the development of therapies for patients with chronic kidney disease.

#Biotechnology

Developing devices for transcatheter mitral valve replacement.

#Medical Technology

Developing conjugate and protein-based vaccines for infectious diseases.

#Biotechnology

Developing pharmaceutical products for the treatment of overactive bladder and irritable bowel syndrome.

#Biotechnology

Developing devices to induce mild therapeutic hypothermia in heart attack and cardiac arrest patients.

#Medical Technology

Markets a suite of products for the reduction of facial wrinkles, rhytides and cellulite.

#Medical Technology

Marketing a range of pain management therapies.

#Biotechnology


Key People

Managing Director

Managing Director

Managing Director

Managing Director

Managing Director and Chief Financial Officer

Managing Director

Managing Director

Managing Director

Associate

Associate

Vice President

Principal

Director of Investor Relations & Marketing

Senior Associate

Principal

Senior Analyst – Public Equities

Venture Partner

Vice President

Associate

Director of Operations & Facilities

Compliance and Legal Associate

Executive Assistant

Executive Assistant

Director of IT

VP of People

Vice President of Finance

Staff Accountant

IRM & Administrative Assistant

Head of Legal and Chief Compliance Officer

Executive Assistant

Senior Tax Manager

Executive Assistant