Apparatus for the treatment of brain affections and method implementing thereof
Inventors
Carpentier, Alexandre • Lafon, Cyril • Chapelon, Jean-Yves • Canney, Michael Sean • Beccaria, Kévin
Assignees
Universite Pierre et Marie Curie • Assistance Publique Hopitaux de Paris APHP • Carthera SAS
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Publication Number
US-8977361-B2
Publication Date
2015-03-10
Expiration Date
Abstract
The present invention relates to an apparatus for the treatment of a brain affection, which comprises at least one implantable generator (4) made of non-ferromagnetic material comprising a casing (7), an ultrasound generating treating device (11) positioned into said casing to induce brain affection treatment by emission of ultrasound waves, and means for fastening the implantable casing into the skull. The apparatus further comprises a power controller (PwC) to supply electricity to the treating device of the implantable generator and to set and control its working parameters, and connecting means (6) to connect the power controller and the treating device of the implantable generator. A method for treating a brain affection with such an apparatus is also disclosed.
Core Innovation
The invention relates to an apparatus for the treatment of a brain affection, in particular brain tumor, comprising at least one MRI compatible implantable generator made of non-ferromagnetic material for implantation into a burr-hole performed in the skull of a patient. The implantable generator includes a casing having at least an upper wall and a lower wall connected together by a peripheral wall, and an ultrasound generating treating device positioned into the casing to induce treatment by emission of ultrasound waves through the lower wall into the brain.
The apparatus further comprises means for fastening the implantable casing into the skull and a power controller to supply electricity to the treating device of the implantable generator and to set and control its working parameters. Connecting means connect the power controller and the treating device, and the implantable generator comprises connecting plugs to accommodate the connecting means and assure connection between the power controller and the treating device.
The connecting plugs comprise transdermic plugs held into the upper wall of the casing and an isolating coating preventing contact with the patient’s skin. The connecting means comprises transdermic needles suitable for plugging into the connecting plugs through the patient’s skin, wherein the transdermic needles are coated with an isolating material except at a tip for contacting the treating device connectors through the connecting plugs.
Claims Coverage
One independent claim is explicitly provided. It covers an MRI compatible, non-ferromagnetic implantable ultrasound generator in a skull burr-hole, together with a power-controller connection scheme through transdermic plugs and needles, including isolating coatings.
Mri compatible non-ferromagnetic implantable generator in a burr-hole
An apparatus comprising at least one MRI compatible implantable generator made of non-ferromagnetic material for implantation into a burr-hole performed in the skull of a patient.
Ultrasound generating treating device in the casing
An ultrasound generating treating device positioned into the casing to induce brain affection treatment by emission of ultrasound waves through the lower wall into the brain.
Fastening means for securing the casing
Means for fastening the implantable casing into the skull.
Power controller for supply and control
A power controller to supply electricity to the treating device and to set and control its working parameters.
Transdermic plugs and needles with isolating coating
Connecting means with transdermic plugs held into the upper wall of the casing and an isolating coating preventing contact with the patient’s skin, and transdermic needles coated with an isolating material except at a tip for contacting the treating device connectors through the connecting plugs.
The claim coverage centers on the implantable ultrasound generator, skull implantation, power control, and transdermic electrical connection through plugs and needles with isolating coatings.
Stated Advantages
MRI compatible operation.
Non-ferromagnetic material.
Transdermic electrical connection with isolating coatings preventing contact with the patient’s skin.
Documented Applications
Treatment of a brain affection, in particular brain tumor.
Contrast-agent-assisted blood-brain barrier opening.
Ultrasound-sensitive drug/nanoparticle release with MRI-visible drug monitoring.
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