System and method for improving the drug therapy management
Inventors
Mougiakakou, Stavroula • Sun, Qingnan • JANKOVIC, Marko • Piveteau, Laurent-Dominique • Proennecke, Stephan • BUDZINSKI, João
Assignees
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Publication Number
US-12112842-B2
Publication Date
2024-10-08
Expiration Date
Abstract
An aspect of the invention provides a method and a product for determining a modification of the therapy management by using a processor unit which retrieves few data related to the blood glucose measurement performed over a predetermined time period; retrieve the medication delivery parameter executed by the delivery device over said predetermined time period; retrieve from the memory data associated to the CIR of the patient; and determine a modification to the therapy based on at least a part of the retrieved data.
Core Innovation
The invention relates to a diabetes management system that provides a daily therapy to a patient by retrieving, from stored data, glucose data comprising at least two glucose measurements performed over a day by a self-monitoring blood glucose device. The system also retrieves stored medication delivery parameter information executed by an insulin delivery device over the day, where the medication delivery parameter includes a basal rate or a bolus, or retrieves Carbohydrate to Insulin Ratio (CIR) information of the patient. The system then determines, based on the retrieved data, a therapy modification including a modification of the basal rate or the CIR.
The therapy modification is intended to the patient for a subsequent time period. The described approach therefore links daily sparse glucose measurement data with prior insulin delivery parameter information and/or CIR information to compute an intended change for a later time period, using the retrieved glucose data and the retrieved medication delivery parameter or CIR information.
In the closed-loop context, the invention further defines diabetes management on a closed loop device by obtaining daily glucose data including at least two measurements over a day and obtaining the medication delivery parameter executed over the day, including a basal rate or a bolus, or obtaining a CIR used for calculating a bolus during the day. The invention determines a set of acceptable data including a basal rate or a CIR to be used for a subsequent time period, compares the acceptable data to data computed by the closed loop device or compares it to the medication delivery parameter intended for the subsequent time-period, and alerts a patient or user or suggests another medication delivery parameter when the compared data do not comply with an acceptable range.
Claims Coverage
The document includes three independent claims: a system, a non-transitory computer-readable medium, and a closed-loop method. Across these claims, the inventive features center on daily glucose data obtained over a day, retrieval of medication delivery parameters and/or CIR, determining a therapy modification or acceptable range for a subsequent time period, and using comparison, alerting, or suggesting another medication delivery parameter to manage a closed loop device.
Daily therapy modification from retrieved glucose and insulin parameters
A diabetes management system configured to retrieve glucose data comprising at least two glucose measurements performed over a day by a self-monitoring blood glucose device, retrieve a medication delivery parameter executed over the day including a basal rate or a bolus, or retrieve CIR information, and determine a therapy modification including a modification of the basal rate or the CIR intended for a subsequent time period.
Device-type independent determination for a subsequent time period
A non-transitory computer readable medium having instructions configured to perform a method for determining a medication delivery parameter or CIR information independently of the type of glucose monitoring device used, including obtaining daily glucose data with at least two measurements over a day, obtaining a medication delivery parameter including a basal rate or a bolus or obtaining a CIR used for calculating a bolus, and determining a medication delivery parameter or CIR for a subsequent time period by taking into account the obtained data.
Acceptable-range comparison and alerting in a closed loop device
A method for performing diabetes management on a closed loop device including obtaining daily glucose data with at least two measurements over a day, obtaining a medication delivery parameter executed over the day including a basal rate or a bolus or obtaining CIR used for calculating a bolus, determining a set of acceptable data including a basal rate or a CIR for a subsequent time period by taking into account the obtained data, comparing the set of acceptable data to data computed by the closed loop device or to the medication delivery parameter intended for the subsequent time-period, and alerting the patient or a user or suggesting another medication delivery parameter when the data do not comply with an acceptable range.
Across the independent claims, the inventive coverage is directed to using daily glucose measurements together with prior insulin delivery parameter data and/or CIR information to determine an updated medication delivery parameter or therapy modification for a subsequent time period, including a closed-loop approach that determines acceptable data for subsequent control and triggers alerting or suggestion when closed-loop computed values fall outside the acceptable range.
Stated Advantages
Not explicitly described in patent.
Documented Applications
Not explicitly described in patent.
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