Composite scaffold for the repair, reconstruction, and regeneration of soft tissues
Inventors
Rocco, Kevin A. • Mohanraj, Bhavana • Ott, Jeffrey • Bendigo, Justin • Komenda, Jacob Edward • Aronson, Mark Theodore • Carter, Andrew James
Assignees
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Publication Number
US-12070384-B2
Publication Date
2024-08-27
Expiration Date
Abstract
A composite scaffold having a highly porous interior with increased surface area and void volume is surrounded by a flexible support structure that substantially maintains its three-dimensional shape under tension and provides mechanical reinforcement during repair or reconstruction of soft tissue while simultaneously facilitating regeneration of functional tissue.
Core Innovation
The invention relates to a scaffold occupying a measurable volume for soft tissue repair. The scaffold includes a three-dimensional support structure having first and second outer layers separated by an interior space, and a plurality of spacer yarns extending through the interior space and connecting the first and second outer layers.
Within the interior space, the scaffold includes a microporous matrix having a multitude of interconnected pores. The interconnected pores collectively define a void space disposed within the interior space between the first and second outer layers, providing an internal porous structure within the composite scaffold.
The scaffold is characterized by a relationship between internal void space surface area and measurable volume, with the void space surface area to measurable volume of the scaffold between approximately 500 cm2/cm3 and 7,000 cm2/cm3. The composite scaffold is defined by outer layers, interior space, spacer yarns, and a microporous matrix.
Claims Coverage
The independent claim defines a composite scaffold occupying a measurable volume, combining a three-dimensional textile support structure with spacer yarns and an interior microporous matrix. The claim includes quantitative coverage of an internal void-space surface-area-to-measurable-volume ratio, and dependent claims further refine mechanical and structural parameters.
Composite scaffold with first and second outer layers separated by interior space
A scaffold occupying a measurable volume comprising a three-dimensional support structure defined by first and second outer layers separated by an interior space.
Spacer yarns connecting outer layers through interior space
A scaffold occupying a measurable volume comprising a plurality of spacer yarns extending through the interior space and connecting the first and second outer layers.
Microporous matrix with interconnected pores defining internal void space
A scaffold occupying a measurable volume comprising a microporous matrix having a multitude of interconnected pores collectively defining void space disposed within the interior space between the first and second outer layers.
Void space surface area to measurable volume ratio
The scaffold wherein the void space surface area to measurable volume of the scaffold is between approximately 500 cm2/cm3 and 7,000 cm2/cm3.
Spacer elements length between outer layers
The scaffold structure having a plurality of spacer elements whose length extending between the first and second outer layers is approximately between 100 μm and 5000 μm.
Modulus range with definition including void space
The scaffold structure having a modulus approximately between 2.5 MPa and 70 MPa, where the modulus is defined as stress divided by strain of a cross-sectional area including the void space.
Ultimate stress range
The scaffold structure having an ultimate stress of approximately between 2.5 MPa and 30 MPa.
Hydrophilic solution coating
The scaffold structure being at least partially coated with a hydrophilic solution.
Hydrophilic solution including polyethylene glycol (PEG)
The scaffold structure in that the hydrophilic solution includes polyethylene glycol (PEG).
Overall, the claim set centers on a scaffold defined by outer layers separated by an interior space with spacer yarns, an interior microporous matrix providing interconnected pores and internal void space, and a specified void-space surface-area-to-measurable-volume ratio. Dependent claims further constrain structural geometry, mechanical parameters, and surface/coating features.
Stated Advantages
Not explicitly described in patent.
Documented Applications
Not explicitly described in patent.
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