Internal organ, injury and pain, pulmonary condition and adipose tissue treatment
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Publication Number
US-11951335-B2
Publication Date
2024-04-09
Expiration Date
Abstract
Ultrasound (US) apparatus and method for applying low energy US onto an internal tissue/organ, including a non-invasive US appliance used on a treatment region over the internal tissue/organ, and an electrical stimulation apparatus for simultaneously inducing interferential electrical stimulation. A controller controls parameters of the electrical stimulation apparatus and the US appliance, and dynamically changes at least one of the parameters, for maintaining the impedance of the body tissue in the treatment region within an impedance range. The US apparatus includes an impedance monitoring apparatus for continuously measuring, tracking, and monitoring impedance in the treatment region, wherein the controller dynamically changes at least one of the parameter in response to the impedance as monitored, for maintaining the impedance within the predefined range. The internal tissue/organ can be a female fertility organ which can be an ovarian follicle, a blood vessel of the uterus (womb), the ovary, the endometrial lining, and the Fallopian tube; a lung, a pulmonary organ, an adipose tissue, ulcer, closed wound, internal injury, inflammation. and nerves.
Core Innovation
The invention relates to an ultrasound (US) apparatus for applying low energy US onto an internal tissue/organ, including a non-invasive external US appliance configured to apply low energy US energy at an US frequency and an US intensity onto a treatment region over the internal tissue/organ. The apparatus also includes an electrical stimulation apparatus that applies interferential electrical stimulation via two pairs of electrodes configured for a crossed configuration on the skin at the treatment region in proximity to the internal tissue/organ. While applying US energy, the electrical stimulation apparatus applies a first current at a first electric frequency and first electric intensity via one electrode pair and a second current at a second electric frequency and second electric intensity via the other electrode pair to define an interference pattern of resonant waves that revolve at an interferential frequency in the treatment region.
The apparatus further includes an impedance monitoring apparatus configured to continuously track and monitor the impedance of body tissue in the treatment region. A controller controls parameters of the electrical stimulation apparatus and the US appliance and dynamically changes at least one of those parameters in response to the monitored impedance, thereby maintaining the impedance within a predefined impedance range. The parameters that are dynamically changed are selected from electrical stimulation parameters consisting of interferential frequency and interference pattern, and ultrasound parameters consisting of US frequency and US intensity.
The internal tissue/organ includes at least one of lung, pulmonary tissue, and adipose tissue. The invention also encompasses a method in which a treatment region is determined and two pairs of electrodes are positioned at crossed configuration to induce interferential electrical stimulation, while simultaneously transmitting US waves at an US frequency and US intensity to the treatment region.
The method continuously monitors impedance and dynamically changes at least one of interferential frequency, interference pattern, US frequency, and US intensity in response to the impedance so as to maintain the impedance within a predefined impedance range. The partial content further defines embodiments by particular pulmonary condition types and by endocrine hormones including leptin, estrogen, resistin, TNFα, adiponectin, PAI-1, IL-6, and estradiol (E2).
Claims Coverage
The partial content provides two independent claims that cover both an apparatus and a method, with additional independent scope-defining refinements based on specified pulmonary conditions and specified endocrine hormones. Across the independents, the core inventive coverage includes simultaneous low energy ultrasound and interferential electrical stimulation with crossed electrode pairs, continuous tissue impedance monitoring, and closed-loop dynamic parameter changes to maintain impedance within a predefined impedance range. The independents explicitly constrain the internal tissue/organ to at least lung, pulmonary tissue, and adipose tissue.
Ultrasound apparatus with interferential stimulation and impedance-maintained dynamic control
An ultrasound (US) apparatus for applying low energy US to an internal tissue/organ, comprising a non-invasive external US appliance; an electrical stimulation apparatus with two crossed electrode pairs applying interferential electrical stimulation by simultaneously delivering first and second currents at respective electric frequencies and intensities to define an interference pattern of resonant waves revolving at an interferential frequency; an impedance monitoring apparatus configured to continuously track and monitor tissue impedance in the treatment region; and a controller configured to dynamically change selected electrical stimulation parameters and ultrasound parameters in response to the monitored impedance to maintain the impedance within a predefined impedance range, wherein the parameters are selected from interferential frequency, interference pattern, US frequency, and US intensity, and wherein the internal tissue/organ comprises at least one of lung, pulmonary tissue, and adipose tissue.
Method of applying low energy US with impedance-maintained dynamic parameter changes
A method for applying low energy ultrasound (US) energy from a non-invasive external US source to an internal body tissue/organ, including determining a treatment region; positioning two pairs of electrodes at crossed configuration for inducing interferential electrical stimulation; applying interferential electrical stimulation by applying a first current at a first electric frequency and first electric intensity via one electrode pair and a second current at a second electric frequency and second electric intensity via another electrode pair to define an interference pattern of resonant waves that revolve at an interferential frequency; transmitting ultrasound (US) waves at an US frequency and an US intensity simultaneously with applying the interferential electrical stimulation; continuously monitoring impedance tracked in the treatment region; and dynamically changing at least one of interferential frequency, interference pattern, US frequency, and US intensity in response to the impedance as monitored to maintain the impedance within a predefined impedance range, wherein the internal tissue/organ comprises at least one of lung, pulmonary tissue, and adipose tissue.
Method scope defined by specified pulmonary condition types
A method wherein the pulmonary condition comprises at least one of alveolar damage, vascular damage, lung ailment, respiratory disorder, respiratory disease, acute or subacute pulmonary pathology or ailment, lung or pulmonary lesions, severe acute respiratory syndrome, acute respiratory distress syndrome (ARDS), pulmonary ailment caused by coronavirus disease 2019 (COVID-19), respiratory failure, pulmonary insufficiency, progressive pulmonary disease, lung conditions encumbered with thrombosis, pulmonary embolism (PE), leakage of fibrin-rich fluid from pulmonary capillaries into alveoli, respiratory disease characterized by widespread inflammation of the lungs due to a buildup of fluid in the alveoli, ARDS caused by or a complication of sepsis, pneumonia, or COVID-19, pulmonary damage with alveolar granulation tissue.
Method scope defined by enumerated endocrine hormones
A method wherein the endocrine hormones comprise leptin, estrogen, resistin, cytokine (particularly TNFα), adiponectin, plasminogen activator inhibitor-1 (PAI-1), IL-6, and/or estradiol (E2).
The independent claim set covers an apparatus and a method that combine low energy ultrasound with interferential electrical stimulation delivered through two crossed electrode pairs, while continuously monitoring tissue impedance and dynamically changing interferential and ultrasound parameters to maintain impedance within a predefined range. The provided independent scope refinements further define embodiments by particular pulmonary condition types and by enumerated endocrine hormones including leptin, estrogen, resistin, TNFα, adiponectin, PAI-1, IL-6, and estradiol (E2).
Stated Advantages
Not explicitly described in patent.
Documented Applications
Not explicitly described in patent.
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