Raman spectroscopy-based optical matched filter system and method for using the same
Inventors
Kersey, Alan • Pandey, Rishikesh • Fournier, David • Root, Gary
Assignees
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Publication Number
US-11725984-B2
Publication Date
2023-08-15
Expiration Date
Abstract
A system for processing Raman scattering light from a sample is provided. The system includes a source, a digital mirror device (DMD), a detector, and an analyzer. The DMD is configured to reflect Raman scattering light and includes micromirrors selectively controllable between ON and OFF states. The detector is configured to detect Raman scattering light and to produce signals representative of the Raman scattering light. The analyzer is in communication with the light source, the DMD, the detector, and a memory storing instructions, which instructions when executed cause the processor to: a) control the light source to produce a beam of light for interrogating the sample; b) control the DMD to place in an ON or OFF state based on one or more known spectral shapes stored in the memory; and c) process the Raman scattering light reflected by the micromirrors in the ON state.
Core Innovation
The invention provides a Raman spectroscopy optical matched-filter system that processes Raman scattering light from a sample using a digital mirror device (DMD). The DMD comprises a plurality of micromirrors that are selectively controllable between at least an ON state and an OFF state, and the analyzer controls the DMD based on one or more known spectral shapes stored in a memory.
The system processes the Raman scattering light reflected by the micromirrors in the ON state and detected by a detector. The stored spectral shapes may include full spectra, partial spectra, or single peaks, and inverse spectral shapes are also disclosed, enabling concordance and out-of-concordance evaluation and a ratio of concordance to out-of-concordance.
To support mapping spectral components onto the DMD, the system uses dispersion optics so that the Raman spectrum is mapped onto the DMD. The description includes embodiments that form an asymmetric image to align Raman peaks to DMD micromirror columns and may further apply filtering or masking of spectral peaks.
The matched-filtering is described as suitable for recognizing subtle tissue changes, including embodiments using optical-domain matched filtering with spectral atoms and sub-atoms, with region operation such as a high wavenumber (HWN) region and example breast tissue spectral atoms and inverse atoms. The disclosed processing uses stored instructions in non-transitory memory executed by the analyzer to interrogate the sample and evaluate the reflected Raman scattering light using the matched-filter spectral shapes.
Claims Coverage
The document contains two independent claims, one system claim and one method claim. Across these claims, the core inventive features are DMD ON/OFF micromirror control using one or more known spectral shapes, and detection and processing of Raman scattering light reflected by ON-state micromirrors.
DMD ON/OFF micromirror control based on known spectral shapes
A DMD comprising a plurality of micromirrors each selectively controllable between at least an ON state and an OFF state, where the analyzer controls the DMD to place respective ones of the plurality of micromirrors in an ON state or an OFF state based on one or more known spectral shapes stored in the memory.
Matched-filter processing of Raman light reflected by ON-state micromirrors
Process Raman scattering light reflected by the micromirrors in the ON state and detected by the detector, using signals representative of the detected Raman scattering light.
Directing Raman scattering light and processing detected ON-state reflected Raman light
Directing a beam of light at the sample to produce Raman scattering light from the sample; controlling the DMD by placing respective ones of the plurality of micromirrors in an ON state or an OFF state based on one or more known spectral shapes; receiving with a detector at least a portion of the Raman scattering light reflected by the plurality of micromirrors in the ON state and producing signals representative of the received at least a portion; and processing the Raman scattering light reflected by the micromirrors in the ON state and detected by the detector using the signals representative of the received at least a portion.
Collectively, the independent claims require a Raman processing system and method in which a DMD selectively reflects Raman scattering light according to patterns derived from one or more known spectral shapes, and an analyzer processes the detected reflected Raman signals from the ON-state micromirrors.
Stated Advantages
Not explicitly described in patent.
Documented Applications
Recognizing subtle tissue changes.
Breast tissue spectral atoms (adipose/benign/cancerous) and tumor margin context.
Spatially offset Raman spectroscopy (SORS) context.
Classification using optical-domain matched-filtering and optional machine learning/AI.
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