Nasal delivery device

Inventors

Shahaf, Daniel • Shichor, Iris • Poran, Yehuda • Poran, Iftah

Assignees

AptarGroup Inc

Abstract

The present invention provides a two-step mechanism for delivering a flowable substance to the nasal passages, comprising: a. a nosepiece adapted to be in fluid connection with said nasal passages; b. at least one air-tight enclosure, comprising predetermined amount of compressed gas in the same; said compressed gas is pressurized to predetermined amount of pressure; c. a charging mechanism, fluidly connected with said air-tight enclosure, characterized by at least two configurations: a retracted position and an extended position; where, when said charging mechanism is transformed from said extended position to said retracted position, said charging mechanism is adapted to enable delivery of said pressurized and predetermined amount of compressed gas from at least one first predetermined position in said air-tight enclosure to at least one second predetermined position; d. an activation mechanism, adapted to entrain said flowable substance within said pressurized and predetermined amount of compressed gas.

Core Innovation

The invention relates to a two-step mechanism for delivering a flowable substance to the nasal passages of a patient. The mechanism comprises a nosepiece configured to be in fluid connection with the nasal passages, and an openable air-tight enclosure configured to contain a predetermined amount of gas compressible to a predetermined amount of pressure.

A charging mechanism is fluidly connected with the air-tight enclosure and has a retracted configuration and an extended configuration. When transformed from the extended configuration to the retracted configuration, the charging mechanism enables delivery of the predetermined amount of gas from at least one first predetermined position in the air-tight enclosure to at least one second predetermined position.

An activation mechanism, upon activation, releases the predetermined amount of gas compressed to the predetermined amount of pressure from the at least one second predetermined position. The released gas entrains the flowable substance within the predetermined amount of gas and delivers it from the second predetermined position to the nasal passages, with activation by application of suction through a mouthpiece connected to the charging mechanism and the activation mechanism.

The two-step mechanism additionally comprises a gas release mechanism selected from a valve mechanism, an air flow regulator, or a rod, spear, needle, or knife configured to pierce an air-tight compartment, including any combination thereof. The charging and delivery architecture is supported by an air-tight piston-in-shaft enclosure and unidirectional valve behavior triggered by suction, including optional gas or air filters and removable and replaceable nosepiece and mouthpiece arrangements.

Claims Coverage

The document includes two independent claims: one device claim and one method claim. Across these claims, the core coverage centers on a predetermined amount of gas in an openable air-tight enclosure, a charging mechanism with retracted and extended configurations, and an activation mechanism that releases the gas to entrain and deliver a flowable substance to nasal passages by suction through a mouthpiece. Three main inventive features are repeatedly defined.

The independent claims collectively define a suction-activated, predetermined compressed gas entrainment system that transfers a flowable substance to nasal passages through a nosepiece, using an extended-to-retracted charging mechanism and a release mechanism comprising a valve, flow regulator, or pierce-type release of the gas from an air-tight enclosure via a mouthpiece.

Stated Advantages

Documented Applications