Prototype Solutions for Optic Nerve Injury
The overarching goal of this program is to provide biomanufacturing for an emerging area of medical technology and innovation to support standard procedures toward a device, biologic, or combination prototype to maintain, re-establish or regenerate damaged visual pathways.
The Awardee will develop an innovative solution to a critical problem in visual loss. Applications were expected to address one or more of the following focus areas in nerve regeneration or end-organ health:
- Enhance optic nerve regeneration.
- Re-establish neuronal connections between retinal ganglion cells and the lateral geniculate nucleus with high efficiency.
This effort aims to promote highly innovative, groundbreaking research; high-impact research with near-term clinical relevance; multidisciplinary, synergistic research; and translational studies to support the fluid transfer of knowledge from basic principles to clinical solutions.
The research project award recipient was selected from the Offerors who responded to MTEC’s Request for Project Proposals (18-02-OpticNerve).
Title of Project: Preservation and Restoration of Vision in Optic Neuropathies: Porcine traumatic model for advancing neuroprotective and regenerative therapies towards human testing
Award Amount: $3,000,000
Project Duration: 3 years
Project Team: Byers Eye Institute at Stanford University (Prime); Boston Children’s Hospital (sub)
Project Objective: The major goals of this project are to develop a large animal model of traumatic optic neuropathy, and to test for efficacy in this new model therapeutic combinations that successfully promote optic nerve regeneration in the rodent.