Columbia University
Columbia University is a leading Ivy League research university in New York City, founded in 1754. It comprises undergraduate and graduate programs across 17+ schools, a world-renowned medical center, and nearly 200 research centers and institutes. The Global Alliance for Preventing Pandemics (GAPP) in the Mailman School of Public Health is dedicated to capacity building through workforce development and democratization of technology to provide public health professionals in the Global South every opportunity to independently identify and contain pathogen outbreaks. GAPP focuses on sharing sustainable technologies and best technical practices involving sequencing, serological, and rapid diagnostics tools so public health teams are poised to achieve their very different goals addressing their varied and evolving needs. GAPP works closely with the US CDC, NIAID, WHO, GOARN, foundations dedicated to global health and medical equity, and local and regional ministries of health and education to address human health, and the ministries of livestock and fisheries to help address food security while fostering a culture of the open sharing of data.
Industries
N/A
Nr. of Employees
small (1-50)
Columbia University
90 Morningside Drive (office); 851-854 Schermerhorn Extension (lab)
Patents
Gene therapy for diseases caused by unbalanced nucleotide pools including mitochondrial DNA depletion syndromes
2025-09-23 • US-12419970-B2
View DetailsCompositions and methods for visible-light-controlled ruthenium-catalyzed olefin metathesis
2025-08-05 • US-12377407-B2
View Details
Gene therapy for diseases caused by unbalanced nucleotide pools including mitochondrial DNA depletion syndromes
2025-09-23 • US-12419970-B2
View DetailsCompositions and methods for visible-light-controlled ruthenium-catalyzed olefin metathesis
2025-08-05 • US-12377407-B2
View DetailsProducts
Review: Functional central-limit theorems and applications
Technical review of functional central limit theorems and their application to renewal, counting and queueing processes and heavy-traffic limits.
Paper: Markov-chain models and sensitivity analysis for lockup/illiquidity premiums
Research presenting CTMC models for state-dependent returns (multi-state structure), including derivation of transient probabilities, eigen-decomposition methods, numerical calibration via nonlinear programming, and sensitivity analysis of liquidity/lockup premiums to persistence, volatility and death probability.
Method: Target-enriched enzymatic methyl sequencing (publication)
Peer-reviewed description of a hybrid-capture and enzymatic method for targeted DNA methylation quantification suitable for scalable use in ecological and evolutionary epigenetics studies.
Software/Method: Transposable-element extraction from reduced-representation datasets
Computational approach for extracting transposable-element composition from reduced-representation sequencing datasets to enable genome-content inference when whole-genome data are unavailable.
Paper: Variable-selection methods for designed experiments with heredity constraints
Methodology extending least-angle regression to enforce heredity principles in variable selection for designed experiments, including algorithms for strong/weak heredity and predictability scoring.
Lecture notes and instructional materials in stochastic processes and Brownian-motion theory
Educational lecture notes covering CTMCs, birth–death processes, Kolmogorov equations, Brownian motion, Gaussian processes, and martingale methods for teaching and reference.
Review: Functional central-limit theorems and applications
Technical review of functional central limit theorems and their application to renewal, counting and queueing processes and heavy-traffic limits.
Paper: Markov-chain models and sensitivity analysis for lockup/illiquidity premiums
Research presenting CTMC models for state-dependent returns (multi-state structure), including derivation of transient probabilities, eigen-decomposition methods, numerical calibration via nonlinear programming, and sensitivity analysis of liquidity/lockup premiums to persistence, volatility and death probability.
Method: Target-enriched enzymatic methyl sequencing (publication)
Peer-reviewed description of a hybrid-capture and enzymatic method for targeted DNA methylation quantification suitable for scalable use in ecological and evolutionary epigenetics studies.
Software/Method: Transposable-element extraction from reduced-representation datasets
Computational approach for extracting transposable-element composition from reduced-representation sequencing datasets to enable genome-content inference when whole-genome data are unavailable.
Paper: Variable-selection methods for designed experiments with heredity constraints
Methodology extending least-angle regression to enforce heredity principles in variable selection for designed experiments, including algorithms for strong/weak heredity and predictability scoring.
Lecture notes and instructional materials in stochastic processes and Brownian-motion theory
Educational lecture notes covering CTMCs, birth–death processes, Kolmogorov equations, Brownian motion, Gaussian processes, and martingale methods for teaching and reference.
Expertise Areas
- Stochastic processes and queueing theory
- Continuous-time Markov chain modeling and transient analysis
- Diffusion approximations and Brownian-motion theory
- Poisson and counting-process modeling
Key Technologies
- Continuous-time Markov chains (generator-matrix methods)
- Matrix exponential computation for transient CTMC probabilities
- Eigen-decomposition for generator matrices
- Functional central limit theorems and diffusion approximations
Key People
Thomas Hunt Morgan Professor of Conservation Biology; Professor, Department of Ecology, Evolution and Environmental Biology; Director / Principal Investigator, Rubenstein Lab (Columbia University)
Professor, Department of Industrial Engineering and Operations Research (author of FCLT review; coauthor of CTMC hedge-fund lockup paper)
Author (Gambler’s Ruin / Stochastic Processes lecture notes), Columbia-affiliated
20th President (named 2023; first female president) — former
Chief Executive Officer, Columbia University Irving Medical Center; appointed Interim President (Aug 2024) before returning to medical center leadership
Board of Trustees Co-Chair; appointed Acting President (Mar 28, 2025)
Thomas Hunt Morgan Professor of Conservation Biology; Professor, Department of Ecology, Evolution and Environmental Biology; Director / Principal Investigator, Rubenstein Lab (Columbia University)
Professor, Department of Industrial Engineering and Operations Research (author of FCLT review; coauthor of CTMC hedge-fund lockup paper)
Author (Gambler’s Ruin / Stochastic Processes lecture notes), Columbia-affiliated
20th President (named 2023; first female president) — former
Chief Executive Officer, Columbia University Irving Medical Center; appointed Interim President (Aug 2024) before returning to medical center leadership
Board of Trustees Co-Chair; appointed Acting President (Mar 28, 2025)
News & Updates
Dustin R. Rubenstein appointed Thomas Hunt Morgan Professor of Conservation Biology at Columbia University (endowed professorship).
Named a Sigma Xi Distinguished Lecturer (2025).
Dustin Rubenstein was named a Sigma Xi Distinguished Lecturer for 2026–2028 (Rubenstein Lab announcement).
Dustin R. Rubenstein elected a Fellow of AAAS in recognition of contributions to science.
Recipient of Columbia University's Lenfest Distinguished Faculty Award.
Named a National Geographic Explorer in recognition of research and field work.
Dustin R. Rubenstein appointed Thomas Hunt Morgan Professor of Conservation Biology at Columbia University (endowed professorship).
Named a Sigma Xi Distinguished Lecturer (2025).
Dustin Rubenstein was named a Sigma Xi Distinguished Lecturer for 2026–2028 (Rubenstein Lab announcement).
Dustin R. Rubenstein elected a Fellow of AAAS in recognition of contributions to science.
Recipient of Columbia University's Lenfest Distinguished Faculty Award.
Named a National Geographic Explorer in recognition of research and field work.